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Medication Safety in Pregnancy

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June 2021

Signal Detection in EUROmediCAT: Identification and Evaluation of Medication-Congenital Anomaly Associations and Use of VigiBase as a Complementary Source of Reference.  Cavadino A, Sandberg L, Öhman I, Bergvall T, Star K, Dolk H, Loane M, Addor MC, Barisic I, Cavero-Carbonell C, Garne E, Gatt M, Khoshnood B, Klungsøyr K, Latos-Bielenska A, Lelong N, Lutke R, Materna-Kiryluk A, Nelen V, Neville A, O'Mahony M, Mokoroa O, Pierini A, Randrianaivo H, Rissmann A, Tucker D, Wiesel A, Yevtushok L, Morris JK. Drug Saf. 2021 Jul;44(7):765-785. doi: 10.1007/s40264-021-01073-z. Epub 2021 May 9. PMID: 33966183.


February 2021

EUROmediCAT researchers have found that azithromycin, an antibiotic being considered for COVID-19 treatment, could be associated with increased risk of atrioventricular septal defect in babies when taken in the first trimester of pregnancy.  Read the article:  Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly:  A European case-control study



January 2021

Report of the Expert Working Group on Optimising Data on Medicines used in Pregnancy


The UK Expert Working Group included EUROmediCAT members (Rachel Charlton, Helen Dolk, Joan Morris) and can be found here:




December 2020  

Professor Sue Jordan of Swansea University and her colleagues recently published the following paper, which suggests that women who stop taking their asthma medicines during pregnancy are at risk of premature birth and are less likely to breastfeed their babies.  As part of the study, the team used data from the Secure Anonymised Information Linkage (SAIL), a state-of-the-art privacy protection system, held at Swansea University and funded by the Welsh Government as part of the national research infrastructure.  

Medicines prescribed for asthma, discontinuation and perinatal outcomes, including breastfeeding: A population cohort analysis Davies G, Jordan S, Thayer D, Tucker D, Humphreys I (2020) Medicines prescribed for asthma, discontinuation and perinatal outcomes, including breastfeeding: A population cohort analysis. PLOS ONE 15(12):e0242489.  


June 2020 - Update to the EUROmediSAFE inventory

As part of our work on the IMI ConcePTION Project the EUROmediSAFE inventory was updated. The Spreadsheet containing all additional Data Sources for the ConcePTION Data Source Catalogue can be found here


This forms part of the Conception Report D1.1 Spreadsheet containing all additional Data Sources for the ConcePTION Data Source Catalogue, which is also now available for viewing and download from the ConcePTION Website by clicking here.


Risk factors for congenital heart disease: The Baby Hearts Study, a population-based case-control study. Dolk H, McCullough, N, Callaghan S, Craig B, Given J, Loane M, Lagan B, Bunting B, Boyle B, Dabir T. PLOS ONE. February 24, 2020.


Use of prescribed contraception in Northern Ireland 2010-2016.  Given J, Gray A, Dolk H. The European Journal of Contraception & Reproductive Health Care. 18 Feb 2020. 


Bayesian hierarchical methods in the detection of potentially teratogenic first-trimester medications. Cavadino A, Prieto-Merino D and Morris JK.  Pharmacoepidemiology and Drug Safety, 6 Jan 2020.